APOE e4, rated life experiences, and affect among centenarians
نویسندگان
چکیده
Peter Martin, S. Michal Jazwinski, Adam Davey, Robert C. Green, Maurice MacDonald, Jennifer A. Margrett, Ilene C. Siegler, Jonathan Arnold, John L. Woodard, Mary Ann Johnson, Sangkyu Kim, Jianliang Dai, Li Li, Mark A. Batzer, Leonard W. Poon and for the Georgia Centenarian Study Department of Human Development and Family Studies, Iowa State University, Ames, IA, USA; Department of Medicine and Tulane Center for Aging, Tulane University, New Orleans, LA, USA; Department of Public Health, Temple University, Philadelphia, PA, USA; Brigham and Women’s Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; School of Family Studies and Human Services, Kansas State University, Manhattan, KS, USA; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine and Department of Psychology and Neuroscience, Duke University, Durham, NC, USA; Department of Genetics, University of Georgia, Athens, GA, USA; Department of Psychology, Wayne State University, Detroit, MI, USA; Department of Foods and Nutrition, University of Georgia, Athens, GA, USA; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA; Institute of Gerontology, University of Georgia, Athens, GA, USA
منابع مشابه
APOE ϵ4, rated life experiences, and affect among centenarians.
OBJECTIVES The purpose of this study was to assess the relationship between apolipoprotein E (APOE), life events and engagement, and subjective well-being (as measured by positive and negative affect) among centenarians. Based on the life stress paradigm, we predicted that higher levels of stress would allow APOE to influence positive and negative affect. METHOD 196 centenarians and near-cent...
متن کاملThe relationship between midlife and late life alcohol consumption, APOE e4 and the decline in learning and memory among older adults.
AIMS The aim of the study was to determine whether the trajectory of learning and memory is modified according to an interaction between midlife or late life alcohol consumption status and the presence of one or more APOE e4 alleles. METHODS This was a secondary analysis of cognitive, genetic and alcohol consumption data collected from members of the Framingham Heart Study Offspring Cohort. ...
متن کاملCorrelates of functional capacity among centenarians.
This study investigated correlates of functional capacity among participants of the Georgia Centenarian Study. Six domains (demographics and health, positive and negative affect, personality, social and economic support, life events and coping, distal influences) were related to functional capacity for 234 centenarians and near centenarians (i.e., 98 years and older). Data were provided by prox...
متن کاملTOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.
Recently, it has been reported that TOMM40 variable-length poly-T sequence polymorphism (rs10524523) in combination with APOE alleles (E2, E3, E4) significantly influences late-onset Alzheimer's disease (LOAD) age of onset. In a group of 414 LOAD patients, 173 centenarians and 305 neurologically healthy individuals, we investigated the impact of TOMM40 poly-T tracts on LOAD incidence, age of on...
متن کاملPolymorphisms in the Apolipoprotein E Region and Severity of Multiple Sclerosis
Background: The apolipoprotein E (APOE) polymorphism is known to affect various neurologic disorders with different effects on the immune system and CNS repair. However, previous studies on possible modulation of the clinical course of multiple sclerosis (MS) by APOE polymorphism have been inconsistent. Objective: To clarify the issue for MS patients' management and future research. Methods: Th...
متن کامل